Promising Molecule Drug aimed to treat cancer
The common aim for the
majority of the biological scientists is to tackle Cancer. Cancer is a growing
complication due to lifestyle changes like long exposure to the UV light,
disrupted sleep cycles, stress, and pollution. Many people experience stress caused
by their workload. For personal or professional reasons it is a common tendency
to compromise sleep which results in a disrupted circadian rhythm. In simple
words, circadian rhythm means the normal sleep cycle of human beings. In
research named”Circadian Rhythm Disruption in Cancer Biology” conducted by
Christos Savvudis and Micheal Koutsilieris, it is cited from the International
Agency for Research on (IARC) 2007 that, “shiftwork that involves circadian
disruption [as] probably carcinogenic to humans”. Therefore, the
disruption in circadian rhythm is linked to the development of cancer in
humans.
Nevertheless, the scientists at the University of
Southern California have used the disrupted circadian rhythm as a tool to treat
cancer. A disrupted body clock negatively affects the functioning of the normal
cells. The same concept applies to the cancer cells. The researchers
hypothesized that if the circadian clock of the cancer cells is disrupted it is
possible to kill or at least hurt the cancer cells (“University”).
The scientists at the University of Southern California
discovered a molecule named GO289 which interacts with a protein which
regulates the circadian rhythm of the cells. This interaction also disrupts the
four other proteins that are essential for cell growth and survival. These
proteins are used by the cancer cells to develop; however, disrupting this
cycle can potentially cease the metastasis or spread of cancer. “The GO289 can
jam the cogs of the cell’s circadian clock, slowing its cycles. And it can do
so with little impact to healthy cells” (“University”).
To test the efficiency of this new drug, “Go289” the
researchers tested it on the human bone cells cancers. It was observed that the
drug slowed the tumors; circadian clock. Additionally, it was tested on the
human kidney cancer cells and the mice with acute myeloid leukemia. GO289
affected cancer cell metabolism and other circadian cycles that contributed to
the growth of cancer.
The above photograph
demonstrates the disrupted circadian rhythm of the human bone cancer cells
caused by the drug molecule, GO289.
Works Cited:
The University of Southern California. (2019, January 23).
Cancer has a biological clock and this drug may keep it from ticking: A
promising drug slows cancer's circadian clock, halts its spread. ScienceDaily.
Retrieved January 27, 2019, from
www.sciencedaily.com/releases/2019/01/190123144524.htm
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